|Coenzyme Q-10 (CoQ-10) - 2CARE||| Print ||
What is a Clinical Trial?by Huntington Study Group (HSG)
Understanding Clinical Trials by NIH ClinicalTrials.gov
List of Clinical Trials by NIH ClinicalTrials.gov
2CARE information from Huntington Study Group (HSG)
Trial information at NIH ClincalTrials.gov
2CARE is the Phase III trial for CoQ-10 that is testing the effectiveness of high doses of this supplement in symptomatic Huntington's individuals with early or mid-stage disease who have maintained independence and are free of active psychiatric symptoms.
Trial status: Started in 2008, is actively recruiting. Will need 608 participants.
Sponsor: National Institutes of Health
Trial design: A randomized, double-blind, placebo controlled trial of
high dose (2400 mg) CoQ-10 compared to placebo in 608 participants. The trial requires 14 visits and 10 telephone contacts over 5 years, but will be stopped
earlier if benefit is shown. Other psychotropic medications and tetrabenazine are allowed if stable dosing has been obtained.
Location: Recruiting is ongoing at 48 Huntington Study Group centers who are participating in this study.
Outcome measures: Comparison of UHDRS (a combination of motor, cognitive,and psychiatric tests) and functional capacity (TFC). It is change in TFC for those on CoQ-10 compared to placebo that will be used to define effectiveness. And MRI of the brain at the beginning and end of the trial will be requested only at specified centers.
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