PRIDE-HD: Why We Should Bother

Posted Feb 18, 2015 by LaVonne Veatch Goodman, M.D.

Recruitment is not going well for PRIDE-HD, an important clinical trial now enrolling for Huntington's disease (HD). Why is this?  Some think "why bother", particularly when testing a drug they may perceive as a failure in earlier trials. For some others, the trials may seem to too hard, too long, or not permit other drugs they are taking.  Still others are waiting for the gene therapy magic bullet they believe is just around the corner.

Maybe we should look a little deeper?

 

 

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Aggression in Huntington's Disease

Posted January 25, 2015 by LaVonne Veatch Goodman, M.D.

A recent article reports that aggression is common in individuals with Huntington's disease. Authors report rates of aggressive behaviors between 22% (for clinic patients) and 66% (for hospitalized patients) among individuals with HD. What do they mean by aggression, and how should we interpret these numbers? It is important to remember that aggression (as defined in this article) and violence are NOT the same thing.

However, the most important thing to learn is not how often it occurs, but how we can understand, cope with and treat aggressive behaviors in HD.

 

 

 

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Treatment Guidelines for Huntington's: Who needs them?

Posted by LaVonne Goodman M.D.

During my years as an internal medicine physician, I have used standard of care guidelines for my patients with conditions like diabetes and heart disease. Guidelines are developed by experts in each disease who translate clinical trial evidence and/or expert experience into recommended care patterns for use in medical offices or at the bedside. When followed, guidelines have been central to improving the quality of care provided by all physicians whether they are specialists or generalists.   

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